Studies may have found key to peanut allergies

Studies may have found key to peanut allergies

Studies may have found key to peanut allergies Probiotics combined with a peanut protein may cure the allergy in most children, new research finds.

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Studies may have found key to peanut allergies

Probiotics combined with a peanut protein may cure the allergy in most children, new research finds.

peanut butter on a spoon sticking out of a jar

Talk to people in their 40s, and they will likely remember kids who brought peanut butter sandwiches to school. Ask a parent today, and they’ll tell you that peanuts aren’t even allowed in the cafeteria.

Food-related allergies have been on the rise for years. Some kids have mild reactions and, for some, peanut allergies are life-threatening. According to the Centers for Disease Control and Prevention (CDC), food allergies among children increased by 18 percent between 1997 and 2007, and food-related allergic reactions have become the most common cause of anaphylaxis in community health settings.

Researchers at the Murdoch Childrens Research Institute in Australia report that they have taken the first few steps to finding a treatment for this common allergy. A new 2017 study shows that two-thirds of the 48 children enrolled in a small clinical trial who received an experimental immunotherapy treatment were cured of their allergy, and the results lasted for four years.

“These children had been eating peanut freely in their diet without having to follow any particular program of peanut intake in the years after treatment was completed,” lead researcher Professor Mimi Tang said in a press release. The results suggest “the exciting possibility that tolerance is a realistic target for treating food allergy. This is a major step forward in identifying an effective treatment to address the food allergy problem in Western societies,” Tang said.

Tang is an immunologist and an allergist who developed a new treatment that combines probiotics with peanut oral immunotherapy (PPOIT). Instead of avoiding peanuts, people with such an allergy take the peanut-protein-laced probiotic to gradually develop a tolerance to peanuts.

Peanuts plus probiotics

The results are a follow-up to a 2015 clinical trial from the same researchers in Australia, where 28 children with peanut allergies were given daily doses of the probiotic Lactobacillus rhamnosus in combination with peanut protein. The amount of probiotic stayed the same while the dose of peanut protein increased over time until the children were receiving two grams a day.

By the end of the trial, more than 80 percent of the children who received treatment (and not the placebo) were able to include peanuts in their diet.

“In the study the combined delivery of probiotic and oral immunotherapy was a safe and effective treatment for peanut allergy,” said Tang of the findings. “However it is important to point out that this treatment must be only be given under close medical supervision as we are giving peanut[s] to children who are allergic to peanut[s], and children did have allergic reactions. Nevertheless, the likelihood of success was high — if nine children were given probiotic and peanut therapy, seven would benefit.”

Tang added, “It appears that we have been able to modify the allergic response to peanut such that the immune system produces protective responses rather than a harmful response to the peanut protein.”

Gradual prevention

The Australian team’s use of gradually introducing peanuts into a child’s diet to ward off an allergic reaction is a process now recommended by the National Institute of Allergy and Infectious Diseases (NIAID), a center that is a part of the National Health Institute.

The panel recommended three guidelines based on a child’s risk factor for developing peanut allergies. Those infants at the highest risk, meaning they’re already showing signs of severe ezcema or allergy, should receive peanut-containing foods as early as 4 to 6 months of age in reduce their risk factor. Those with a medium risk should wait until 6 months to have peanut foods introduced at 6 months old. Infants who do not display any signs of an allergic reaction should eat as much peanut food as parents and doctors see fit.

NIAD made these recommendations based on studies that have suggested early exposure to peanuts can reduce allergy risk. While the Australian study above was not cited, a study from the New England Journal of Medicine published in February 2015 “showed that regular peanut consumption begun in infancy and continued until 5 years of age led to an 81 percent reduction in development of peanut allergy in infants deemed at high risk.”

This story was originally written in February 2015 and has been updated with new information.